Oleh Khalimonchuk, PhD, FAAAS

Avatar for Oleh Khalimonchuk, PhD, FAAAS

Oleh Khalimonchuk, PhD, FAAAS

Willa Cather Professor of Biochemistry and Director, Nebraska Redox Biology Center Biochemistry University of Nebraska-Lincoln

Contact

Address
BEAD N230
Lincoln NE 68588-0664
Phone
402-472-8060 On-campus 2-8060
Email
okhalimonchuk2@unl.edu
Social Media

Research Strengths

Biomedical Research, Lipids/Membrane biochemistry, Molecular Signaling, Redox biology

Mitochondria are highly dynamic and complex organelles responsible for cellular energy conversion, a plethora of key metabolic pathways, maintenance of ion homeostasis and programmed cell death. Perturbations of mitochondrial homeostasis and integrity result in dysfunctions that manifest in a spectrum of early to adult-onset neurological and cardiovascular disorders and are contributor to certain types of cancer, type II diabetes and neurodegeneration. Understanding the molecular bases of mitochondrial function/dysfunction is a key for finding ways to combat these currently incurable disorders. Our research utilizes yeast and mammalian cell models to address following questions:


1.   Role of the protein quality control in mitochondrial homeostasis and stress response
 

2.   Biogenesis and maintenance of the protein complexes within the inner mitochondrial membrane

 

Khalimonchuk Lab