Research

Research Overview

The class H Stabilin receptors comprise a family of 2 known members in mammals.  Stabilin-1 (MS-1, FEEL-1, CLEVER-1) and Stabilin-2 (HARE, FEEL-2) are 315-320 kDa receptors with an overall identity of 41%.  Both receptors are type 1 scavenger receptors expressed in a wide variety of tissues including liver, spleen, lymph node, bone marrow, and specialized structures of the kidney, brain, and eye.  Although both receptors use clathrin-coated internalization mechanisms, the cytoplasmic domains are very different from one another and their trafficking within the cell is also quite disparate.  Stab2 is expressed as two isoforms as illustrated below in approximately 1:1 ratio.  This is a result of proteolytic cleavage and not related to a genetic component of the cell or tissue type.

Heparin and Phosphorothioate(PS)-Modified Antisense Oligonucleotides (ASOs) are ligands of greatest interest to Stab 1 and Stab 2 binding. These are both important pharmaceutical compounds that are cleared rapidly from circulation by both Stabilin receptors.

Heparin

Phosphorothioate (PS)-modified antisense oligonucleotide