Harris Lab
Selected Publications
1. Kayashima, Y., Connor C.A., Lewis A.M. Sun. X., Hiller S., Huynh P., Wilder J., Hagaman J., Li F., Maeda-Smithies, N., Harris, E.N. (2022) Reduction of Stabilin-2 Contributes to a Protection against Atherosclerosis. Front in Cardiovasc Med. Mar 11. Doi: 10.3389/fcvm.2022.818662. [PMID:35360009].
2. Cabral F., Al-Rahem M., Skaggs J., Thomas T.A., Kumar N., Wu Q., Fadda P., Yu L., Robinson J.M., Kim J., Pandey E., Sun X., Jarjour W.N., Rajaram M.V.S., Harris E.N. Ganesan, L.P. (2021) Stabilin Receptors Clear LPS and Control Systemic Inflammation. iScience 25:24(11):103337, doi: 10.1016/j.isci.2021.103337 [PMCID:PMC5891421].
3. Harris E.N. Will Inhibition of Cellular Crosstalk Resolve Liver Fibrosis? (2022) Hepatology Jan 26 doi: 10.1002/hep.32361. [PMID:35080050].
4. Pandey E., Nour A.S., Harris, E.N. (2020) Prominent Receptors of Liver Sinsusoidal Endothelial Cells in Liver Homeostatsis and Disease. Front Physiol 2020;11:873. Doi:10.3389/pfhys.2020.00873. [PMCID:PMC7311747].
5. Sun, X. and Harris E.N. (2020) New Aspects of Hepatic Endothelial Cells in Physiology and Nonalcoholic Fatty Liver Disease. Am J Physiol Cell Physiol. June 318(6):C1200-1213. Doi 10.1152/ajpcell.0062.2020. [PMID:32374676].
6. Harris E.N. and Baker. E (2020) Role of the Hyaluronan Receptor, Stabilin-2/HARE, in Health and Disease. Int. J. Mol. Sci. May 15; 21(10). Doi:10.3390/ijms21103504. [PMID:32429122].
7. Harris E.N. and Cabral F. (2019) Ligand Binding and Signaling of HARE/Stabilin-2 (Review). Biomolecules Jul 9(7). pii: E273. doi: 10.3390/biom9070273 [PMCID:PMC6681266].
8. Natarajan G., Perriotte-Olson, C., Casey, C.A., Donohue, T.M., Talmon, G.A., Harris, E.N., Kabanov, A.V., Saraswathi, V., (2018) Effect of Copper/Zinc Superoxide Dismutase Nanozyme on Chronic Ethanol-Induced Alterations in Liver and Adipose Tissue. Alcohol 79:71-9. doi 10.1016/j.alcohol.2018.12.005. [PMCID:PMC6610811].
9. Pirie, E., Ray, S., Pan, C., Fu, W., Powers, A.F., Polikoff, D., Miller, C.M., Kudrna, K.M., Harris, E.N., Lusis, A.J., Crooke, R.M., Lee, R.G. (2018) Mouse Genome-wide Association Studies and Systems Genetics Uncover the Genetic Architecture Associated with Hepatic Pharmacokinetic and Pharmacodynamic Properties of a Constrained Ethyl Antisense Oligonucleotide Targeting Malat1. PLoS Genetics In Revision
10. Miller, C.M., Xu, Y., Kudrna, K.M., Hass, B.E., Kellar, B.M., Egger, A.W., Liu, J., Harris, E.N. (2018) 3-O Sulfation of Heparin Leads to Hepatotropism and Longer Circulatory Half-life. Thromb. Res. 167:80-87. [PMID:29793137]
11. Bano, F., Tammi, M.I., Kang, D.W., Harris, E.N., Richter, R.P., (2018) Force Response of Single Molecular Interactions between the Extracellular Matrix Polysaccharide Hyaluronan and its Binding Proteins. Biophys J. 114(12):2910-2922. [PMID:29925027].
12. Gaus, H., Miller, C.M., Seth, P.P., Harris, E.N. (2018) Structural Determinants for the Internalization of Chemically Modified Nucleic Acids with the Stabilin-2 Clearance Receptor. ACS Biochem 57(14):2061-2064. [PMID:29589907].
13. Srivastava, T., Diba, P., Dean, J.M., Banine, F., Shaver, D., Hagen, M., Gong, X., Su, W., Emery, B., Marks, D.L., Harris, E.N., Baggenstoss, B.A., Weigel, P.H., Sherman, L.S., Back, S.A. (2018) The TLR/AKT/FoxO3 Immune Tolerance-like Pathway Disrupts the Repair Capacity of Oligodendrocyte Progenitors. J Clin Invest 128(5):2025-2041 [PMID:29664021].
14. Miller, C.M., Wan, W.B., Seth, P.P., Harris, E.N. (2018) Endosomal Escape of ASOs Internalized by Stabilin Receptors is Regulated by Rab5C and EEA1 During Endosomal Maturation. Nucleic Acid Ther. Feb 13. doi:10.1089/nat2017.0694. [PMID:29437530].
15. Miller, C.M., Tanowitz, M., Donner, A.J., Prakash, T.P., Harris, E.N., Seth, P.P., (2018) Receptor-Mediated Uptake of Phosphorothioate Antisense Oligonucleotides in Different Cell Types of the Liver. Nucleic Acid Ther. Feb 13. doi: 10.1089/nat.2017.0694. [PMID:29425080].
16. Cabral, F., Miller, C.M., Kudrna, K.M., Hass, B.E., Daubendiek, J.G., Kellar, B.M., Harris, E.N. (2018) Purification of Hepatocytes and Sinusoidal Endothelial Cells from Mouse Liver Perfusion. J. Vis. Exp (JOVE) Feb 12 (132) doi:10.3791/56993. [PMID:29553556]
17. Beck, J.R., Harris, E.N., Stains, C.I., (2017) Quantification of Cell Signaling Networks Using Kinase Acitvity Chemosensors. Methods Mol. Bio. 1636:61-70. [PMID:28730472].
18. Natarajan, V., Harris, E.N., Kidambi, S (2017) SECs (Sinusoidal Endothelial Cells), Microenvironment, and Fibrosis. Biomed. Res. Int. 10.1155/2017/4097205 [PMID:28293634]
19. Miller, Colton M. and Harris, Edward N. (2016) Antisense Oligonucleotides: treatment strategies and cellular internalization. RNA and Disease, doi: 10.14800/rd.1393. [PMID:28374018].
20. Pandey, M.S., Miller, C.M., Harris, E.N., Weigel, P.H. (2016) Activation of ERK and NF-kB during HARE-Mediated Heparin Uptake Require Only One of the Four Endocytic Motifs. PLoS One, 11(4):e0154124. [PMID:27100626].
21. Rasineni, K., Penrice, D.D., Natarajan, S.K., McNiven, M.A., McVicker, B.L., Kharbanda, K., Casey, C.A., Harris, E.N. (2016) Alcoholic vs Non-Alcoholic Fatty Liver in Rats: Distinct Differences in Endocytosis and Vesicle Trafficking despite Similar Pathology. BMC Gastroenterology, 16(1):27 doi 10.1186/s12876-016-0433-4. [PMID:26924554].
22. Miller C.M., Donner, A.J., Blank, E.K., Egger, A.W., Kellar, B.M., Seth, P.P., Harris, E.N. (2016) Stabilin-1 and Stabilin-2 are specific receptors for the cellular internalization of phosphorothioate-modified antisense oligonucleotides. Nucleic Acids Research, 44(6):2782-94. [PMID:26908652].
9. Pirie, E., Ray, S., Pan, C., Fu, W., Powers, A.F., Polikoff, D., Miller, C.M., Kudrna, K.M., Harris, E.N., Lusis, A.J., Crooke, R.M., Lee, R.G. (2018) Mouse Genome-wide Association Studies and Systems Genetics Uncover the Genetic Architecture Associated with Hepatic Pharmacokinetic and Pharmacodynamic Properties of a Constrained Ethyl Antisense Oligonucleotide Targeting Malat1. PLoS Genetics In Revision
10. Miller, C.M., Xu, Y., Kudrna, K.M., Hass, B.E., Kellar, B.M., Egger, A.W., Liu, J., Harris, E.N. (2018) 3-O Sulfation of Heparin Leads to Hepatotropism and Longer Circulatory Half-life. Thromb. Res. 167:80-87. [PMID:29793137]
11. Bano, F., Tammi, M.I., Kang, D.W., Harris, E.N., Richter, R.P., (2018) Force Response of Single Molecular Interactions between the Extracellular Matrix Polysaccharide Hyaluronan and its Binding Proteins. Biophys J. 114(12):2910-2922. [PMID:29925027].
12. Gaus, H., Miller, C.M., Seth, P.P., Harris, E.N. (2018) Structural Determinants for the Internalization of Chemically Modified Nucleic Acids with the Stabilin-2 Clearance Receptor. ACS Biochem 57(14):2061-2064. [PMID:29589907].
13. Srivastava, T., Diba, P., Dean, J.M., Banine, F., Shaver, D., Hagen, M., Gong, X., Su, W., Emery, B., Marks, D.L., Harris, E.N., Baggenstoss, B.A., Weigel, P.H., Sherman, L.S., Back, S.A. (2018) The TLR/AKT/FoxO3 Immune Tolerance-like Pathway Disrupts the Repair Capacity of Oligodendrocyte Progenitors. J Clin Invest 128(5):2025-2041 [PMID:29664021].
14. Miller, C.M., Wan, W.B., Seth, P.P., Harris, E.N. (2018) Endosomal Escape of ASOs Internalized by Stabilin Receptors is Regulated by Rab5C and EEA1 During Endosomal Maturation. Nucleic Acid Ther. Feb 13. doi:10.1089/nat2017.0694. [PMID:29437530].
15. Miller, C.M., Tanowitz, M., Donner, A.J., Prakash, T.P., Harris, E.N., Seth, P.P., (2018) Receptor-Mediated Uptake of Phosphorothioate Antisense Oligonucleotides in Different Cell Types of the Liver. Nucleic Acid Ther. Feb 13. doi: 10.1089/nat.2017.0694. [PMID:29425080].
16. Cabral, F., Miller, C.M., Kudrna, K.M., Hass, B.E., Daubendiek, J.G., Kellar, B.M., Harris, E.N. (2018) Purification of Hepatocytes and Sinusoidal Endothelial Cells from Mouse Liver Perfusion. J. Vis. Exp (JOVE) Feb 12 (132) doi:10.3791/56993. [PMID:29553556]
17. Beck, J.R., Harris, E.N., Stains, C.I., (2017) Quantification of Cell Signaling Networks Using Kinase Acitvity Chemosensors. Methods Mol. Bio. 1636:61-70. [PMID:28730472].
18. Natarajan, V., Harris, E.N., Kidambi, S (2017) SECs (Sinusoidal Endothelial Cells), Microenvironment, and Fibrosis. Biomed. Res. Int. 10.1155/2017/4097205 [PMID:28293634]
19. Miller, Colton M. and Harris, Edward N. (2016) Antisense Oligonucleotides: treatment strategies and cellular internalization. RNA and Disease, doi: 10.14800/rd.1393. [PMID:28374018].
20. Pandey, M.S., Miller, C.M., Harris, E.N., Weigel, P.H. (2016) Activation of ERK and NF-kB during HARE-Mediated Heparin Uptake Require Only One of the Four Endocytic Motifs. PLoS One, 11(4):e0154124. [PMID:27100626].
21. Rasineni, K., Penrice, D.D., Natarajan, S.K., McNiven, M.A., McVicker, B.L., Kharbanda, K., Casey, C.A., Harris, E.N. (2016) Alcoholic vs Non-Alcoholic Fatty Liver in Rats: Distinct Differences in Endocytosis and Vesicle Trafficking despite Similar Pathology. BMC Gastroenterology, 16(1):27 doi 10.1186/s12876-016-0433-4. [PMID:26924554].
22. Miller C.M., Donner, A.J., Blank, E.K., Egger, A.W., Kellar, B.M., Seth, P.P., Harris, E.N. (2016) Stabilin-1 and Stabilin-2 are specific receptors for the cellular internalization of phosphorothioate-modified antisense oligonucleotides. Nucleic Acids Research, 44(6):2782-94. [PMID:26908652].
23. Beck, J.R., Lawrence, A., Tung, A.S., Harris, E.N., Stains, C.I. (2016) Interrogating Endogenous Protein Phosphatase Activity with Rationally Designed Chemosensors. ACS Chemical Biology 11(1):284-90. [PMID:26580981].
24. Krumbeck J.A., Maldonado-Gomez, M.X., Martinez, I., Frese, S.A., Burkey, T.E., Rasineni, K., Ramer-Tait, A., Harris, E.N., Hutkins, R.W., Walter, J. (2015) Introducing the Concept of In Vivo Selection to Identify Pro-biotic Strains for Synergistic Synbiotic Applications. Appl Environ Microbiol. 81(7):2455-65 [PMID:25616794].
25. Pandey, M.S., Harris, E.N., Weigel, P.H. (2015) HARE-mediated Endocytosis of Hyaluronan and Heparin is Targeted by Different Subsets of Three Endocytic Motifs. Int. J. Cell Biol 2015:524707. [PMID:25883656].
26. Hare, A.K. and Harris, E.N. (2015) Tissue-Specific Splice Variants of HARE/Stabilin-2 are expressed in Bone Marrow, Lymph Node, and Spleen. Biochem Biophys Res Commun 456(1):257-61. [PMID:25446080].
27. Xu Y., Cai C., Chandarajoti K., Hsieh P., Li L., Pham TQ., Sparkenbaugh EM., Sheng J., Key NS., Pawlinski R., Harris E.N., Linhardt RJ., Liu J. (2014) Homogenous and Reversible Low-Molecular Weight Heparins. Nat. Chem Biol. 10(4):248-50 [PMID:24561662].
28. Pandey, M.S., Baggenstoss, B.A., Washburn, J., Harris, E.N., Weigel, P.H. (2013) The Hyaluronan Receptor for Endocytosis (HARE) Activates NF-kB- mediated Gene Expression in Response to 40-400 kDa, but Not Smaller or Larger, Hyaluronans. J. of Biol. Chem. 288(20):14068-79 [PMID: 23530033].
29. Harris, E.N. (2012) Heparin Clearance by Liver Scavenger Receptors. Biochem Anal Biochem, http://dx.doi.org/10.4172/2161-1009.1000e114.
30. Pempe, EH, Yongmei, X., Gopalakrishnan, S., Liu, J., Harris, E.N. (2012) Probing the Structural Selectivity of Synthetic Heparin Binding to the Stabilin Receptors. J. of Biol. Chem 287(25):20774-83. [PMID: 22547069].
31. Gopalakrishnan, S. and Harris, E.N. (2011) In vivo liver endocytosis followed by purification of liver cells by liver perfusion. J. of Vis. Exp. (JOVE) Nov 10;(57). pii: 3138. doi: 10.3791/3138. (15,002 views from 390 Universities, Research Institutes and Government Agencies as of 7/17/2015). [PMID:22105014].
24. Krumbeck J.A., Maldonado-Gomez, M.X., Martinez, I., Frese, S.A., Burkey, T.E., Rasineni, K., Ramer-Tait, A., Harris, E.N., Hutkins, R.W., Walter, J. (2015) Introducing the Concept of In Vivo Selection to Identify Pro-biotic Strains for Synergistic Synbiotic Applications. Appl Environ Microbiol. 81(7):2455-65 [PMID:25616794].
25. Pandey, M.S., Harris, E.N., Weigel, P.H. (2015) HARE-mediated Endocytosis of Hyaluronan and Heparin is Targeted by Different Subsets of Three Endocytic Motifs. Int. J. Cell Biol 2015:524707. [PMID:25883656].
26. Hare, A.K. and Harris, E.N. (2015) Tissue-Specific Splice Variants of HARE/Stabilin-2 are expressed in Bone Marrow, Lymph Node, and Spleen. Biochem Biophys Res Commun 456(1):257-61. [PMID:25446080].
27. Xu Y., Cai C., Chandarajoti K., Hsieh P., Li L., Pham TQ., Sparkenbaugh EM., Sheng J., Key NS., Pawlinski R., Harris E.N., Linhardt RJ., Liu J. (2014) Homogenous and Reversible Low-Molecular Weight Heparins. Nat. Chem Biol. 10(4):248-50 [PMID:24561662].
28. Pandey, M.S., Baggenstoss, B.A., Washburn, J., Harris, E.N., Weigel, P.H. (2013) The Hyaluronan Receptor for Endocytosis (HARE) Activates NF-kB- mediated Gene Expression in Response to 40-400 kDa, but Not Smaller or Larger, Hyaluronans. J. of Biol. Chem. 288(20):14068-79 [PMID: 23530033].
29. Harris, E.N. (2012) Heparin Clearance by Liver Scavenger Receptors. Biochem Anal Biochem, http://dx.doi.org/10.4172/2161-1009.1000e114.
30. Pempe, EH, Yongmei, X., Gopalakrishnan, S., Liu, J., Harris, E.N. (2012) Probing the Structural Selectivity of Synthetic Heparin Binding to the Stabilin Receptors. J. of Biol. Chem 287(25):20774-83. [PMID: 22547069].
31. Gopalakrishnan, S. and Harris, E.N. (2011) In vivo liver endocytosis followed by purification of liver cells by liver perfusion. J. of Vis. Exp. (JOVE) Nov 10;(57). pii: 3138. doi: 10.3791/3138. (15,002 views from 390 Universities, Research Institutes and Government Agencies as of 7/17/2015). [PMID:22105014].
1. Kayashima, Y., Connor C.A., Lewis A.M. Sun. X., Hiller S., Huynh P., Wilder J., Hagaman J., Li F., Maeda-Smithies, N., Harris, E.N. (2022) Reduction of Stabilin-2 Contributes to a Protection against Atherosclerosis. Front in Cardiovasc Med. Mar 11. Doi: 10.3389/fcvm.2022.818662. [PMID:35360009]