Harris Lab

Selected Publications

1.      Pandey, E and Harris, E.N. (2023) Chloroquine and Cytosolic Galectins Affect Endosomal Escape of Antisense Oligonucleotides after Stabilin-Mediated Endocytosis.  Mol Ther Nucleic Acids. 19:33:430. Doi 10.1016/j.omtn.2023.07.019 PMCID[PMC10412722]
2.   Wade, H., Pan, K., Duan, Q., Kaluzny, S., Pandey, E., Fatumoju, L., Saraswathi, V., Wu, R., Harris, E.N., Su, Q.  (2023) Akkermansia muciniphila and its Membrane Protein Ameliorates Intestinal Inflammatory Stress and Promotes Epithelial Wound Healing va CREBH and miR-143/145.  J. of Biomed Sci 30(1):38. doi: 10.1186/s12929-00935-1.  [PMCID:PMC10249216]


3.   Saraswathi, V., Kumar N., Ai W., Gopal T., Bhatt S., Harris E.N., Talmon G.A., Desouza C.V. (2022)  Myristic Acid Supplementation aggravates High Fat Diet-Induced Adipose Inflammation and Systemic Insulin Resistance in Mice.  Biomolecules 12(6):739 doi: 10.3390/biom12060739. [PMCID:PMC9220168]

 4.   Kayashima, Y., Connor C.A., Lewis A.M. Sun. X., Hiller S., Huynh P., Wilder J., Hagaman J., Li F., Maeda-Smithies, N., Harris, E.N.  (2022) Reduction of Stabilin-2 Contributes to a Protection against Atherosclerosis.  Front in Cardiovasc Med.  Mar 11. Doi: 10.3389/fcvm.2022.818662. [PMCID:PMC8963368]

 5.   Pattipeiluhu R., Arias-AlPizar G., Basha G., Chan KYT., Bussmann J., Sharp T.H., Moradi M.A., Sommerdijk N., Harris E.N., Cullis P.R., Kros A., Witzigmann D., Campbell F.  (2022) Anionic Lipid Nanoparticles Preferentially Deliver mRNA to the Hepatic Reticuloendothelial System.  Adv. Mater. Feb 25.  Doi: 10.1002/adma.202201095. [PMCID:PMC9461706]

 6.   Harris E.N.  Will Inhibition of Cellular Crosstalk Resolve Liver Fibrosis?  (2022) Hepatology Jan 26 doi: 10.1002/hep.32361. [PMCID:PMC9429820]

 7.   Cabral F., Al-Rahem M., Skaggs J., Thomas T.A., Kumar N., Wu Q., Fadda P., Yu L., Robinson J.M., Kim J., Pandey E., Sun X., Jarjour W.N., Rajaram M.V.S., Harris E.N. Ganesan, L.P.  (2021)  Stabilin Receptors Clear LPS and Control Systemic Inflammation.  iScience 25:24(11):103337, doi: 10.1016/j.isci.2021.103337 [PMCID:PMC5891421].

 8.    Kumar S., Duan Q., Wu R., Harris E.N., Su Q (2021)  Pathophysiological Communication between hepatocytes and non-parenchymal cells in liver injury from NAFLD to liver fibrosis.  Adv Drug Deliv Rev 176:113869 doi: 10.1016/j.addr.2021.113869.  [PMID:3428515]

 9.    Ro S.H., Fay J., Cyuzozo C.I. Jang Y., Lee N., Song H.S., Harris E.N.  (2020) SESTRINs:  Emerging Dynamic Stress-Sensors in Metabolic and Environmental Health.  Front Cell Dev Biol 3;8:603421. doi: 10.3389/fcell.2020.603421 [PCMID:PMC7797007].

 10.  Pandey E., Nour A.S., Harris, E.N. (2020) Prominent Receptors of Liver Sinsusoidal Endothelial Cells in Liver Homeostatsis and Disease.  Front Physiol 2020;11:873.  Doi:10.3389/pfhys.2020.00873.  [PMCID:PMC7311747]

 11.  Sun, X. and Harris E.N. (2020)  New Aspects of Hepatic Endothelial Cells in Physiology and Nonalcoholic Fatty Liver Disease.  Am J Physiol Cell Physiol.  June 318(6):C1200-1213. Doi 10.1152/ajpcell.0062.2020.  [PMCID:PMC7311747].

 12.  Harris E.N. and Baker. E (2020) Role of the Hyaluronan Receptor, Stabilin-2/HARE, in Health and Disease.  Int. J. Mol. Sci.  May 15; 21(10). Doi:10.3390/ijms21103504. [PMCID:PMC7279005].

 13.   Gopal, T., Kumar, N., Perriotte-Olson, D., Casey, C.A., Donohue Jr, T.M., Harris, E.N., Talmon, G., Kabanov, A.V., Saraswathi, V. (2019) Nanoformulated Superoxide Dismutase Ameliorates Alcohol-Associated Liver Disease in Obesity Partly via Regulating CYP2E1 Expression in Adipose Tissue and Liver.  Am. J. Physiol-Gastrointest and Liver Physiology. 318(3):G428-G439.  Doi:10.1152/ajpgi.00217.2019. [PMCID:PMC7099493].

 14.  Beck, J.R., Cabral, F., Rasineni, K., Casey, C.A., Harris, E.N., Stains, C.I. (2019)  A Panel of Kinase Chemosensors Reveals Distinct Signaling Differences in Fatty Liver Disease Models.  ACS Biochem. 58(37), 3911-17. [PMCID:PMC6820001].

 15.  Harris E.N. and Cabral F.  (2019)  Ligand Binding and Signaling of HARE/Stabilin-2 (Review).  Biomolecules Jul 9(7). pii: E273. doi: 10.3390/biom9070273  [PMCID:PMC6681266].

 16.  Barrett, S.T., Thompson, B.M., Emory, J.R., Larsen, C.E., Pittenger, S.T., Harris, E.N., Bevins, R.A.  (2019)  Sex Differences in the Reward-Enhancing Effects of Nicotine on Ethanol Reinforcement:  A Reinforcer Demand Analysis.  Nicotine & Tobacco Research pii:ntz056. April 2019, Doi:10.1093/ntr/ntz056. [PMCID:PMC7297098]

 17.  Natarajan G., Perriotte-Olson, C., Casey, C.A., Donohue, T.M., Talmon, G.A., Harris, E.N., Kabanov, A.V., Saraswathi, V., (2019) Effect of Copper/Zinc Superoxide Dismutase Nanozyme on Chronic Ethanol-Induced Alterations in Liver and Adipose Tissue.  Alcohol 79:71-79. doi: 10.1016/j.alcohol.2018.12.005. [PMCID: PMC6610811].

 18.  Rasineni, K., Thomes, P.G., Kubik, J.L., Harris, E.N., Kharbanda, K.K., Casey, C.A. (2019) Chronic Alcohol Exposure Alters Circulating Insulin and Ghrelin Levels:  Role of Ghrelin in Hepatic Steatosis. Am J. of Physiolog-Gastroint and Liver Physiology 316(4):G453-G461. doi: 10.1152/ajpgi.00334.2018. [PMCID:PMC6483023].

 19.  Pirie, E., Ray, S., Pan, C., Fu, W., Powers, A.F., Polikoff, D., Miller, C.M., Kudrna, K.M., Harris, E.N., Lusis, A.J., Crooke, R.M., Lee, R.G. (2018) Mouse Genome-wide Association Studies and Systems Genetics Uncover the Genetic Architecture Associated with Hepatic Pharmacokinetic and Pharmacodynamic Properties of a Constrained Ethyl Antisense Oligonucleotide Targeting Malat1.  PLoS Genetics 14(10): e1007732  [PMCID:PMC6224167].

 20.  Miller, C.M., Xu, Y., Kudrna, K.M., Hass, B.E., Kellar, B.M., Egger, A.W., Liu, J., Harris, E.N. (2018) 3-O Sulfation of Heparin Leads to Hepatotropism and Longer Circulatory Half-life. Thromb. Res.  167:80-87. [PMCID:PMC6242777].

 21.  Bano, F., Tammi, M.I., Kang, D.W., Harris, E.N., Richter, R.P., (2018) Force Response of Single Molecular Interactions between the Extracellular Matrix Polysaccharide Hyaluronan and its Binding Proteins.  Biophys J.  114(12):2910-2922. [PMCID:PMC6026378].

 22.  Gaus, H., Miller, C.M., Seth, P.P., Harris, E.N. (2018) Structural Determinants for the Internalization of Chemically Modified Nucleic Acids with the Stabilin-2 Clearance Receptor.  ACS Biochem 57(14):2061-2064. [PMCID:PMC5905987].

 23.  Srivastava, T., Diba, P., Dean, J.M., Banine, F., Shaver, D., Hagen, M., Gong, X., Su, W., Emery, B., Marks, D.L., Harris, E.N., Baggenstoss, B.A., Weigel, P.H., Sherman, L.S., Back, S.A. (2018) The TLR/AKT/FoxO3 Immune Tolerance-like Pathway Disrupts the Repair Capacity of Oligodendrocyte Progenitors. J Clin Invest  128(5):2025-2041 [PMCID:PMC5919806].

 24.     Miller, C.M., Wan, W.B., Seth, P.P., Harris, E.N. (2018) Endosomal Escape of ASOs Internalized by Stabilin Receptors is Regulated by Rab5C and EEA1 During Endosomal Maturation.  Nucleic Acid Ther. Feb 13. doi:10.1089/nat2017.0694. [PMCID:PMC5899299].

 25.     Miller, C.M., Tanowitz, M., Donner, A.J., Prakash, T.P., Harris, E.N., Seth, P.P., (2018) Receptor-Mediated Uptake of Phosphorothioate Antisense Oligonucleotides in Different Cell Types of the Liver.  Nucleic Acid Ther. Feb 13. doi: 10.1089/nat.2017.0694. [PMCID:PMC6037193].

 26.     Cabral, F., Miller, C.M., Kudrna, K.M., Hass, B.E., Daubendiek, J.G., Kellar, B.M., Harris, E.N. (2018) Purification of Hepatocytes and Sinusoidal Endothelial Cells from Mouse Liver Perfusion.  J. Vis. Exp (JOVE) Feb 12 (132) doi:10.3791/56993.  [PMCID:PMC5894826].

27.     Beck, J.R., Harris, E.N., Stains, C.I., (2017)  Quantification of Cell Signaling Networks Using Kinase Activity Chemosensors.  Methods Mol. Bio. 1636:61-70. [PMCID:PMC6623968].

 28.     Natarajan, V., Harris, E.N., Kidambi, S (2017) SECs (Sinusoidal Endothelial Cells), Microenvironment, and Fibrosis.  Biomed. Res. Int. 10.1155/2017/4097205 [PMCID:PMC5331310].

 29.     Baggenstoss, B.A., Harris, E.N., Washburn, J.L., Medina, A.P., Nguyen, L. Weigel, P.H. (2017)  Hyaluronan Synthase Control of Synthesis Rate and Hyaluronan Product Size are Independent Functions Differently Affected by Mutations in a Conserved Tandem B-X7-B motif.  Glycobiology 27(2):154-164. [PMCID:PMC5224591].

 30.     Miller, Colton M. and Harris, E.N.  (2016) Antisense Oligonucleotides:  treatment strategies and cellular internalization.  RNA and Disease, doi: 10.14800/rd.1393. [PMCID:PMC5376066].

 31.      Pandey, M.S., Miller, C.M., Harris, E.N., Weigel, P.H. (2016) Activation of ERK and NF-kB during HARE-Mediated Heparin Uptake Require Only One of the Four Endocytic Motifs. PLoS One, 11(4):e0154124. [PMCID:PMC4839745].

 32.      Rasineni, K., Penrice, D.D., Natarajan, S.K., McNiven, M.A., McVicker, B.L., Kharbanda, K., Casey, C.A., Harris, E.N. (2016) Alcoholic vs Non-Alcoholic Fatty Liver in Rats:  Distinct Differences in Endocytosis and Vesicle Trafficking despite Similar Pathology.  BMC Gastroenterology, 16(1):27 doi 10.1186/s12876-016-0433-4.  [PMCID:PMC4770635].

 33.          Miller C.M., Donner, A.J., Blank, E.K., Egger, A.W., Kellar, B.M., Seth, P.P., Harris, E.N. (2016) Stabilin-1 and Stabilin-2 are specific receptors for the cellular internalization of phosphorothioate-modified antisense oligonucleotides. Nucleic Acids Research,  44(6):2782-94. [PMCID:PMC4824115].34.      Beck, J.R., Lawrence, A., Tung, A.S., Harris, E.N., Stains, C.I.  (2016)  Interrogating Endogenous Protein Phosphatase Activity with Rationally Designed Chemosensors.  ACS Chemical Biology 11(1):284-90.  [PMID:26580981].

 35.      Krumbeck J.A., Maldonado-Gomez, M.X., Martinez, I., Frese, S.A., Burkey, T.E., Rasineni, K., Ramer-Tait, A., Harris, E.N., Hutkins, R.W., Walter, J. (2015) Introducing the Concept of In Vivo Selection to Identify Pro-biotic Strains for Synergistic Synbiotic Applications. Appl Environ Microbiol.  81(7):2455-65 [PMCID:PMC4357922].

 36.      Pandey, M.S., Harris, E.N., Weigel, P.H. (2015) HARE-mediated Endocytosis of Hyaluronan and Heparin is Targeted by Different Subsets of Three Endocytic Motifs.  Int. J. Cell Biol 2015:524707. [PMCID:PMC4390207].

 37.      Hare, A.K. and Harris, E.N.  (2015)  Tissue-Specific Splice Variants of HARE/Stabilin-2 are expressed in Bone Marrow, Lymph Node, and Spleen. Biochem Biophys Res Commun 456(1):257-61. [PMCID:PMC4276495].

 38.      Xu Y., Cai C., Chandarajoti K., Hsieh P., Li L., Pham TQ., Sparkenbaugh EM., Sheng J., Key NS., Pawlinski R., Harris E.N., Linhardt RJ., Liu J.  (2014) Homogenous and Reversible Low-Molecular Weight Heparins. Nat. Chem Biol. 10(4):248-50 [PMCID:PMC4393012].

 39.    Pandey, M.S., Baggenstoss, B.A., Washburn, J., Harris, E.N., Weigel, P.H. (2013) The Hyaluronan Receptor for Endocytosis (HARE) Activates NF-kB- mediated Gene Expression in Response to 40-400 kDa, but Not Smaller or Larger, Hyaluronans.  J. of Biol. Chem. 288(20):14068-79 [PMCID:PMC3656264].

 40.     Harris, E.N. (2012) Heparin Clearance by Liver Scavenger Receptors. Biochem Anal Biochem,

 41.     Pempe, EH, Yongmei, X., Gopalakrishnan, S., Liu, J., Harris, E.N. (2012) Probing the Structural Selectivity of Synthetic Heparin Binding to the Stabilin Receptors.  J. of Biol. Chem 287(25):20774-83. [PMCID:PMC3375502].

 42.         Gopalakrishnan, S. and Harris, E.N. (2011) In vivo liver endocytosis followed by purification of liver cells by liver perfusion.  J. of Vis. Exp. (JOVE) Nov 10;(57). pii: 3138. doi: 10.3791/3138. (15,002 views from 390 Universities, Research Institutes and Government Agencies as of 7/17/2015). [PMCID:PMC3308580].

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