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Research Overview
Our research program is focused on the two major thiol-based redox buffers of the cell, thioredoxin and glutathione. These two biomolecules are largely responsible for the tightly controlled maintenance of intracellular reduction-oxidation status essential for normal cellular function. We use protein crystallography in combination with site-directed mutagenesis, enzymology, protein chemistry, and other biophysical techniques, to examine the biological functions of the enzymes responsible for maintaining reduced glutathione and thioredoxin reservoirs.
In addition to redox homeostsis, we are also involved in several collaborative projects focused on structure and function relationships in enzymes of biomedical significance. Most recently, we have been collaborating with the Simpson Lab on enzymes involved in hyaluronan metabolism.
Research Overview
Our research program is focused on the two major thiol-based redox buffers of the cell, thioredoxin and glutathione. These two biomolecules are largely responsible for the tightly controlled maintenance of intracellular reduction-oxidation status essential for normal cellular function. We use protein crystallography in combination with site-directed mutagenesis, enzymology, protein chemistry, and other biophysical techniques, to examine the biological functions of the enzymes responsible for maintaining reduced glutathione and thioredoxin reservoirs.
In addition to redox homeostsis, we are also involved in several collaborative projects focused on structure and function relationships in enzymes of biomedical significance. Most recently, we have been collaborating with the Simpson Lab on enzymes involved in hyaluronan metabolism.
